| ncRNA name | p53 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell lines Y79 |
| Methods | immunocytochemistry, Western blot, Annexin V stainning, flow cytometry, siRNA transfection |
| Expression pattern | associated |
| Functional description | Nutlin 3A induced cell death in Y79 and WERI-RB-1 in the 5- to 10-microM dose range. Y79 cells expressing siRNA against p53 demonstrated resistance to Nutlin 3A. |
| PubMed ID | 16966622 |
| Year | 2006 |
| Title | Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells. |
| Drug-related ncRNA | NO |
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